Moving boxes and picture cropping

Hi, I realise that if all of the boxes are aligned nicely (and not overlapping other brics/blocs ie: over 2 blocs) then the following could be done quite easily, but is this achievable given the overlaps of columns etc? Done in Muse for ease of example.

BTW: one more thing, is there anyway to crop a picture to the bounding box size, as when I import/place, the box resizes to the proportions of the picture?

Yet again… thanks in advance for any pointers.